The article will explore the regional differences in supplement use, supplement safety, anti-doping policies, and the adoption of third-party tested supplements across different continents. It will examine how cultural, regulatory, and economic factors influence the prevalence of supplements in sports nutrition and how athletes' access to safe, tested products varies globally. The article will highlight the role of anti-doping organizations in shaping policies and enforcement, comparing approaches in regions such as North America, Europe, Asia, and Oceania. It will also address the challenges and benefits of third-party testing and certification programs in ensuring supplement safety and compliance with anti-doping regulations. Through this analysis, the article aims to provide a comprehensive understanding of the global landscape of supplement use in sports and offer insights into improving safety and standardization across different regions, written by representatives from these regions. As part of this initiative PINES provides a one-year free membership for individuals who are not already members, in recognition of their contribution to the project.